Chemistry of drug metabolism (Fishman, William H.)

William H. Carmalt

chemistry, metabolism, and toxicology of cannabis: clinical implications.

cannabis is one of the most widely abused substances throughout the world. the primary psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (▵(9_)thc), produces a myriad of pharmacological effects in animals and humans. although it is used as a recreational drug, it can potentially lead to dependence and behavioral disturbances and its heavy use may increase the risk for psychotic...

Opiate Chemistry and Metabolism

To determine whether or not one of these drugs has been taken it is important to understand their respective metabolic pathways (the chain of reactions that they undergo in the body) to know which chemicals are indicative of the use of any opiate and which are indicative of the use of an illicit opiate such as heroin. Once this is known then urine samples can be analysed for these chemicals and...

STUDIES ON b-GLUCURONIDASE* I. A METHOD OF PREPARATION AND PURIFICATION BY W. H. FISHMAN

The preparation of an extract from animal tissues containing an enzyme specific for the hydrolysis of &glucuronides was first described by Masamune (1). Oshima (2,3) later studied the distribution of this enzyme in the tissues of the dog and the ox and improved the method of preparation of active extracts. At the suggestion of Professor G. F. Marrian an investigation was undertaken to determine...

STUDIES ON b-GLUCURONIDASE* I. A METHOD OF PREPARATION AND PURIFICATION BY W. H. FISHMAN

The preparation of an extract from animal tissues containing an enzyme specific for the hydrolysis of &glucuronides was first described by Masamune (1). Oshima (2,3) later studied the distribution of this enzyme in the tissues of the dog and the ox and improved the method of preparation of active extracts. At the suggestion of Professor G. F. Marrian an investigation was undertaken to determine...